New iron(III) anti-cancer aminobisphenolate/phenanthroline complexes: Enhancing their therapeutic potential using nanoliposomes
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 623, 2022
Cristina P. Matos , Melissa Albino , Joana Lopes , Ana Silveira Viana , Leonor Côrte-Real , Filipa Mendes , Joao Costa Pessca , Ana Isabel Tomaz , Catarina Pinto Reis , M. Manuela Gaspar , Isabel Correia

Biotinylated Polymer-Ruthenium Conjugates: In Vitro and In Vivo Studies in a Triple-Negative Breast Cancer Model
PHARMACEUTICS, 14, 2022
Leonor Côrte-Real , Ana Rita Brás , Adhan Pilon , Nuno Mendes , Ana Sofia Ribeiro , Tiago D. Martins , José Paulo Farinha , M. Conceição Oliveira , Fatima Gartner , M. Helena Garcia , Ana Preto , Andreia Valente

Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, , 2022
Brittany F. Karas , Cathleen L. Doherty , Kristin R. Terez , Leonor Côrte-Real , Keith R. Cooper , Brian T. Buckley

Anticancer Activity and In Vitro to In Vivo Mechanistic Recapitulation of Novel Ruthenium-Based Metallodrugs in the Zebrafish Model
TOXICOLOGICAL SCIENCES, 182, 29-43 2021
Brittany F. Karas , Jordan M. Hotz , Brian M. Gural , Kristin R. Terez , Victoria L. DiBona , Leonor Côrte-Real , Andreia Valente , Brian T. Buckley , Keith R. Cooper

A New Family of Iron(II)-Cyclopentadienyl Compounds Shows Strong Activity against Colorectal and Triple Negative Breast Cancer Cells
MOLECULES, 25, 4 2020
Adhan Pilon , Ana Rita Brás , Leonor Côrte-Real , Fernando Avecilla , Paulo J. Costa , Ana Preto , M. Helena Garcia , Andreia Valente

Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 163, 853-863 2 2019
Leonor Côrte-Real , Brittany Karas , Patricia Girio , Alexis Moreno , Fernando Avecilla , Fernanda M. Marques , Brian T. Buckley , Keith R. Cooper , Cathleen Doherty , Pierre Falson , M. Helena Garcia , Andreia Valente

A novel screening method for transition metal-based anticancer compounds using zebrafish embryo-larval assay and inductively coupled plasma-mass spectrometry analysis
JOURNAL OF APPLIED TOXICOLOGY, 39, 1173-1180 8 2019
Brittany F. Karas , Leonor Côrte-Real , Cathleen L. Doherty , Andreia Valente , Keith R. Cooper , Brian T. Buckley

Ruthenium-Cyclopentadienyl Bipyridine-Biotin Based Compounds: Synthesis and Biological Effect
INORGANIC CHEMISTRY, 58, 9135-9149 7 2019
Leonor Côrte-Real , Brittany Karas , Ana Rita Brás , Adhan Pilon , Fernando Avecilla , Fernanda Marques , Ana Preto , Brian T. Buckley , Keith R. Cooper , Cathleen Doherty , M. Helena Garcia , Andreia Valente

Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
European Journal of Medicinal Chemistry , 143, 503-514 2018
Ricardo G. Teixeira , Ana Rita Brás , Leonor Côrte-Real , Rajendhraprasad Tatikonda , Anabela Sanches , M Paula Robalo , Fernado Avecilla , Tiago Moreira , M. Helena Garcia , Matti Haukka , Ana Preto , Andreia Valente

Methyl-cyclopentadienyl Ruthenium Compounds with 2,2?-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential
Inorganic Chemistry, , 4 2018
Leonor Côrte-Real , Ricardo G. Teixeira , Patricia Girio , Elisabeta Comsa , Alexis Moreno , Rachad Nasr , Hélène Baubichon-Cortay , Fernando Avecilla , Fernanda M. Marques , M Paula Robalo , Paulo Mendes , Joao P. Prates Ramalho , M. Helena Garcia , Pierre Falson , Andreia Valente

Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 143, 503-514 1 2018
Ricardo G. Teixeira , Ana Rita Brás , Leonor Côrte-Real , Rajendhraprasad Tatikonda , Anabela Sanches , M Paula Robalo , Fernando Avecilla , Tiago Moreira , M. Helena Garcia , Matti Haukka , Ana Preto , Andreia Valente

Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes
JOURNAL OF INORGANIC BIOCHEMISTRY, 168, 27-37 3 2017
Orsolya Doemoetoer , R. F. M. de Almeida , Leonor Côrte-Real , Cristina P. Matos , Fernanda M. Marques , Antonio Matos , Carla Real , Tamas Kiss , Eve Anna Enyedy , M. Helena Garcia , Ana Isabel Tomaz

The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds
JOURNAL OF INORGANIC BIOCHEMISTRY, 150, 148-159 9 2015
Leonor Côrte-Real , M Paula Robalo , Fernanda M. Marques , Guilherme Nogueira , Fernando Avecilla , Tiago J. L. Silva , Filipa C. Santos , Ana Isabel Tomaz , M. Helena Garcia , Andreia Valente

New iron(II) cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leukemia cancer cells
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 756, 52-60 4 2014
Andreia Valente , Ana Margarida Santos , Leonor Côrte-Real , M Paula Robalo , Virtudes Moreno , Merce Font-Bardia , Teresa Calvet , Julia Lorenzo , M. Helena Garcia

New water-soluble ruthenium(II) cytotoxic complex: Biological activity and cellular distribution
JOURNAL OF INORGANIC BIOCHEMISTRY, 130, 1-14 1 2014
Tânia S. Morais , Filipa C. Santos , Tiago F. Jorge , Leonor Côrte-Real , Paulo J. Amorim Madeira , Fernanda M. Marques , M Paula Robalo , Antonio Matos , Isabel Santos , M. Helena Garcia

Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 19, 853-867 8 2014
Leonor Côrte-Real , Filipa Mendes , Joana Coimbra , Tânia S. Morais , Ana Isabel Tomaz , Andreia Valente , M. Helena Garcia , Isabel Santos , Manuel Bicho , Fernanda M. Marques

Biological activity and cellular uptake of [Ru(eta(5)-C5H5)(PPh3)(Me(2)bpy)][CF3SO3] complex
JOURNAL OF INORGANIC BIOCHEMISTRY, 122, 8-17 5 2013
Tânia S. Morais , Filipa C. Santos , Leonor Côrte-Real , Fernanda M. Marques , M Paula Robalo , Paulo J. Amorim Madeira , M. Helena Garcia

Exploring the effect of the ligand design on the interactions between [Ru(eta(5)-C5H5)(PPh3)(N,O)][CF3SO3] complexes and human serum albumin
JOURNAL OF INORGANIC BIOCHEMISTRY, 129, 94-101 12 2013
Tânia S. Morais , Filipa C. Santos , Leonor Côrte-Real , M. Helena Garcia

Cellular Uptake Mechanisms of an Antitumor Ruthenium Compound: The Endosomal/Lysosomal System as a Target for Anticancer Metal-Based Drugs
MICROSCOPY AND MICROANALYSIS, 19, 1122-1130 10 2013
Leonor Côrte-Real , A. P. Alves de Matos , Irina Alho , Tânia S. Morais , Ana Isabel Tomaz , M. Helena Garcia , Isabel Santos , Manuel Bicho , Fernanda M. Marques